Genes in the Ureteric Budding Pathway: Association Study on Vesico-Ureteral Reflux Patients

Genes in the Ureteric Budding Pathway: Association Study on Vesico-Ureteral Reflux Patients

Vesico-ureteral reflux (VUR) is the retrograde passage of urine from the bladder to the urinary tract and causes 8.5% of end-stage renal disease in children. It is a complex genetic developmental disorder, in which ectopic embryonal ureteric budding is implicated in the pathogenesis. VUR is part of the spectrum of Congenital Anomalies of the Kidney and Urinary Tract (CAKUT). We performed an ext...

Vesico - ureteric reflux

Vesicoureteral reflux (VUR) is the retrograde flow of urine from the bladder into the ureter. A normally functioning ureteral vesical junction (UVJ) allows for the smooth expulsion of urine from the ureter into the bladder without regurgitation of urine back up the ureter, either during bladder filling or upon voiding, If this valvular mechanism fails, from whatever etiology, urine flowing back...

Vesico-ureteric reflux.

Vesico-ureteric reflux and reflux nephropathy.

Physiopathology of vesico-ureteral reflux

Vescico-Ureteral Reflux (VUR) is a common condition in childhood, caused by a congenital anomaly at the Vescico-Ureteral Junction (VUJ) level. It seems that the main cause could be an abnormal embryological development occurred during the early stage of fetal life.Refluxing ureteral endings show structural and functional anomalies: previous studies have shown a significant decrease in alfa acti...